Publications

Selected Recent Publications

Lopaschuk GD. (2017) Metabolic Modulators in Heart Disease: Past, Present, and Future. Can J Cardiol [Epub ahead of print] Review. PMID: 28279520.

De Jong KA, Czeczor JK, Sithara S, McEwen K, Lopaschuk GD, Appelbe A, Cukier K, Kotowicz M and McGee SL. (2017) Obesity and type 2 diabetes have additive effects on left ventricular remodelling in normotensive patients-a cross sectional study. Cardiovasc Diabetol 16(1):21. PMID: 28178970.

Rines AK, Chang HC, Wu R, Sato T, Khechaduri A, Kouzu H, Shapiro J, Shang M, Burke MA, Jiang X, Chen C, Rawlings TA, Lopaschuk GD, Schumacker PT, Abel ED and Ardehali H. (2017) Snf1-related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling. Nat Commun 8:14095. PMID: 28117339.

Lopaschuk GD and Ussher JR. (2016) Evolving Concepts of Myocardial Energy Metabolism: More Than Just Fats and Carbohydrates. Circ Res 119(11):1173-1176. PMID: 28051784.

Lopaschuk GD. (2016) Fatty Acid Oxidation and Its Relation with Insulin Resistance and Associated Disorders. Ann Nutr Metab 68 Suppl 3:15-20PMID: 27931032.

Lopaschuk GD and Verma S. (2016) Empagliflozin's Fuel Hypothesis: Not so Soon. Cell Metab 24(2):200-2. PMID: 27508868.

Fukushima A and Lopaschuk GD. (2016) Acetylation control of cardiac fatty acid β-oxidation and energy metabolism in obesity, diabetes, and heart failure. Biochim Biophys Acta 1862(12):2211-2220. PMID: 27479696.

Groenendyk J, Lee D, Jung J, Dyck JR, Lopaschuk GD, Agellon LB and Michalak M. (2016) Inhibition of the Unfolded Protein Response Mechanism Prevents Cardiac Fibrosis. PLoS One 11(7):e0159682. PMID: 27441395.

Akhnokh MK, Yang FH, Samokhvalov V, Jamieson KL, Cho WJ, Wagg C, Takawale A, Wang X, Lopaschuk GD, Hammock BD, Kassiri Z and Seubert JM. (2016) Inhibition of Soluble Epoxide Hydrolase Limits Mitochondrial Damage and Preserves Function Following Ischemic Injury. Front Pharmacol 7:133. PMID: 27375480.

Fukushima A, Alrob OA, Zhang L, Wagg CS, Altamimi T, Rawat S, Rebeyka IM, Kantor PF and Lopaschuk GD. (2016) Acetylation and succinylation contribute to maturational alterations in energy metabolism in the newborn heart. Am J Physiol Heart Circ Physiol 311(2):H347-63. PMID: 27261364.

Lopaschuk GD. (2016) Preface to the BBA special issue "heart lipid metabolism". Biochim Biophys Acta 1860(10):1423-4. PMID: 27208401.

Ussher JR, Fillmore N, Keung W, Zhang L, Mori J, Sidhu VK, Fukushima A, Gopal K, Lopaschuk DG, Wagg CS, Jaswal JS, Dyck JR and Lopaschuk GD. (2016) Genetic and Pharmacological Inhibition of Malonyl CoA Decarboxylase Does Not Exacerbate Age-Related Insulin Resistance in Mice. Diabetes 65(7):1883-91. PMID: 27207536.

Taegtmeyer H, Young ME, Lopaschuk GD, Abel ED, Brunengraber H, Darley-Usmar V, Des Rosiers C, Gerszten R, Glatz JF, Griffin JL, Gropler RJ, Holzhuetter HG, Kizer JR, Lewandowski ED, Malloy CR, Neubauer S, Peterson LR, Portman MA, Recchia FA, Van Eyk JE, Wang TJ; American Heart Association Council on Basic Cardiovascular Sciences. (2016) Assessing Cardiac Metabolism: A Scientific Statement From the American Heart Association. Circ Res 118(10):1659-701. PMID: 27012580.

Fukushima A and Lopaschuk GD. (2016) Cardiac fatty acid oxidation in heart failure associated with obesity and diabetes. Biochim Biophys Acta 1860(10):1525-34. PMID: 26996746.

Lopatin YM, Rosano GM, Fragasso G, Lopaschuk GD, Seferovic PM, Gowdak LH, Vinereanu D, Hamid MA, Jourdain P and Ponikowski P. (2016) Rationale and benefits of trimetazidine by acting on cardiac metabolism in heart failure. Int J Cardiol 203:909-15. PMID: 26618252.